Search Southwest Illinois hotels
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Southwest Illinois
Pet friendly
Apartment
Apart hotel
Condo
Spa pool
Cottage
Family friendly
Waterpark
Cabin
Check prices for these dates
Tonight
20 Aug - 21 AugTomorrow
21 Aug - 22 AugThis weekend
21 Aug - 23 AugNext weekend
28 Aug - 30 AugOur top choices for Southwest Illinois hotels
1. Drury Plaza Hotel Mt. Vernon
Drury Plaza Hotel Mt. VernonMount Vernon
Kirstyn
AU$176
includes taxes & fees
28 Aug - 29 Aug
2. Best Western U. S. Inn
Best Western U. S. InnNashville
James
AU$184
includes taxes & fees
6 Sept - 7 Sept
3. Super 8 by Wyndham Okawville
Super 8 by Wyndham OkawvilleOkawville
Peter
AU$101
includes taxes & fees
6 Sept - 7 Sept
4. Best Western Plus MidAmerica Hotel
Best Western Plus MidAmerica HotelMascoutah
Justin
AU$161
includes taxes & fees
30 Aug - 31 Aug
5. Holiday Inn Express Hotel & Suites Sparta by IHG
Holiday Inn Express Hotel & Suites Sparta by IHGSparta
Keisha
AU$157
includes taxes & fees
6 Sept - 7 Sept
6. Seasons Inn & Suites Highland
Seasons Inn & Suites HighlandHighland
Patricia
AU$132
includes taxes & fees
23 Aug - 24 Aug
7. SureStay Hotel by Best Western Whittington Rend Lake
SureStay Hotel by Best Western Whittington Rend LakeWhittington
Debbie
AU$126
includes taxes & fees
26 Aug - 27 Aug
8. Comfort Suites Mount Vernon
Comfort Suites Mount VernonMount Vernon
Erica
AU$193
includes taxes & fees
23 Aug - 24 Aug
9. The Principal Hotel
The Principal HotelColumbia
Daniel
AU$163
includes taxes & fees
8 Sept - 9 Sept
10. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake
Fairfield Inn & Suites by Marriott Mt. Vernon Rend LakeMount Vernon
Blake
AU$173
includes taxes & fees
29 Aug - 30 Aug
11. Drury Inn & Suites St. Louis O'Fallon, IL
Drury Inn & Suites St. Louis O'Fallon, ILO'Fallon
KEVIN
AU$173
includes taxes & fees
30 Aug - 31 Aug
12. Super 8 by Wyndham Mt. Vernon IL
Super 8 by Wyndham Mt. Vernon ILMount Vernon
Matthew W,
AU$112
includes taxes & fees
23 Aug - 24 Aug
13. Country Hearth Inn & Suites Edwardsville St. Louis
Country Hearth Inn & Suites Edwardsville St. LouisEdwardsville
les
AU$176
includes taxes & fees
24 Aug - 25 Aug
14. Best Western Plus Centralia Hotel & Suites
Best Western Plus Centralia Hotel & SuitesCentralia
Corey
AU$234
includes taxes & fees
23 Aug - 24 Aug
15. Holiday Inn Express & Suites Mount Vernon by IHG
Holiday Inn Express & Suites Mount Vernon by IHGMount Vernon
Angela D
AU$170
includes taxes & fees
20 Sept - 21 Sept
16. Powhatan Motel
Powhatan MotelPocahontas
Michele
AU$144
includes taxes & fees
21 Aug - 22 Aug
17. Red Bud Country Inn
Red Bud Country InnRed Bud
Richard
AU$120
includes taxes & fees
21 Aug - 22 Aug
18. Comfort Inn & Suites Greenville I-70
Comfort Inn & Suites Greenville I-70Greenville
Alan
AU$155
includes taxes & fees
20 Sept - 21 Sept
19. Quality Inn Mount Vernon, IL
Quality Inn Mount Vernon, ILMount Vernon
Kristin
AU$114
includes taxes & fees
20 Sept - 21 Sept
20. Baymont by Wyndham Chester IL
Baymont by Wyndham Chester ILChester
Keng
AU$114
includes taxes & fees
30 Aug - 31 Aug
Stay near popular Southwest Illinois attractions
O'Fallon Family Sports Park
8.6/10 (137 reviews)
Explore the great outdoors at O'Fallon Family Sports Park, a lovely green space in O'Fallon. Visit the shops and top-notch restaurants in this family-friendly area.
World Wide Technology Raceway
9.0/10 (2 reviews)
Catch an event at World Wide Technology Raceway during your trip to St. Louis. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
DuQuoin State Fairgrounds
8.2/10 (95 reviews)
Catch an event at DuQuoin State Fairgrounds during your trip to Du Quoin. Experience the area's festivals and live music.
Learn more about Southwest Illinois
Explore a “natural city” of trees, enjoy incredible hilltop views, marvel at geological wonders and hop between small towns in this beautiful region.
See all hotels in Southwest Illinois
Photo by Carl Anderson
Top Southwest Illinois Hotel Reviews
Recent Reviews in Southwest Illinois
Drury Inn & Suites St. Louis Fairview Heights
10/10 Excellent
"Wonderful stay. Everything was great"
Comfort Suites Fairview Heights - St. Louis
8/10 Good
"This hotel is conveniently located."
Drury Plaza Hotel Mt. Vernon
10/10 Excellent
"We have been here several times over the years. We love the place, my daughter had surgery on Wednesday morning, so we came down the night before. The kick back hour is always great. And breakfast was delicious as always, and the lady that puts it all together is great, she actually remembered us again. Love the place, might be back later this fall."
The Principal Hotel
10/10 Excellent
"Rooms were large and clean - the bed very comfortable"
Comfort Inn Edwardsville - St. Louis
8/10 Good
"Breakfast was vary goods Well stocked"
Drury Inn & Suites St. Louis O'Fallon, IL
10/10 Excellent
"Nice"
Super 8 by Wyndham Collinsville St. Louis
10/10 Excellent
"It’s a cool place to stay for some days they don’t have a pool or a gym but hey it’s a pool spot up the street and there area is lit up with all types of restaurants"
More cheap accommodation in Southwest Illinois
Super 8 by Wyndham O'Fallon
1100 Eastgate Dr O'Fallon IL
AU$90
22 Aug - 23 Aug
includes taxes & fees
6.6/10 (1,081 reviews)
Comfort Suites Fairview Heights - St. Louis
137 Ludwig Dr Fairview Heights IL
AU$120
20 Sept - 21 Sept
includes taxes & fees
6.4/10 (1,008 reviews)
Best Western St. Louis Fairview Heights
150 Ludwig Dr Fairview Heights IL
AU$127
30 Aug - 31 Aug
includes taxes & fees
Baymont by Wyndham Marion
2608 W Main St Marion IL
AU$147
8 Sept - 9 Sept
includes taxes & fees
Best Western U. S. Inn
11640 State Route 127 Nashville IL
AU$184
6 Sept - 7 Sept
includes taxes & fees
Comfort Suites Mount Vernon
404 South 44th Street Mount Vernon IL
AU$193
23 Aug - 24 Aug
includes taxes & fees
Explore a world of travel with Expedia
- Ava Hotels
- Baldwin Hotels
- Makanda Inn
- Budget Inn by Hotel O Greensville I 70
- Briarwood Inn of Sparta
- Hunter's Retreat
- Holiday Inn Express & Suites Edwardsville by IHG
- Collinsville Hotels
- Edwardsville Hotels
- Farina Hotels
- Flora Hotels
- Cabin Rentals in Freeburg
- Godfrey Hotels
- Hamel Hotels
- Herrin Hotels
- Hoyleton Hotels
- Marion Hotels
- Lgbt Welcoming Hotels in O'Fallon
- Shiloh Hotels
- Sorento Hotels
- Caravan Parks in Swansea
- Lgbt Welcoming Hotels in Vandalia
- Whittington Hotels
- Zeigler Hotels
